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Head of the Department of Dentistry · Universidad Austral de Chile

Dr. Diego Halabi

DDS, PhD in Medical Sciences

I study how circadian and metabolic disruption shape oral and systemic health, and build the software that makes this research and teaching reproducible.

Upcoming: Director, Diploma in Clinical Epidemiology (2027)

Dr. Diego Halabi

01Profile

I'm a clinician-scientist working at the intersection of chronobiology, metabolic physiology, and systemic health. For over a decade I've studied how circadian disruption during pregnancy (chronodisruption) programs metabolic and cardiovascular disease in the offspring, and how maternal melatonin can prevent it in animal models. This work has been published in journals such as The Journal of Physiology, Journal of Pineal Research, and Frontiers in Endocrinology.

Fluorescent adipocytes

Trained as a dentist and now Head of the Department of Dentistry, I connect oral and systemic health through the perio-systemic axis, the biological link between periodontal disease, obesity, and adipose-tissue inflammation.

In parallel, I build and deploy the software that supports this work, from automated assessment tools and reproducible-research platforms to the Linux infrastructure that runs them, bringing engineering rigor to academic and clinical workflows.

02Research

My work follows three connected lines, from the lab bench to the clinic.

Cosinor model fit in RStudio
Cosinor model fit in R, quantifying circadian rhythms.

Methods

  • Clinical trials, observational studies and systematic reviews (Cochrane certification).
  • Logistic regression, multivariate and cosinor models in R (tidyverse) and Python.
  • Reproducible, fully scripted reports with RMarkdown and LaTeX.
  • Cell culture and experimental surgery in rodent models.

03Software

I build the tools my teaching and research need, and ship them when they are useful to others.

EvaLumina for Mac showing an evaluation's grading scale and grade distribution
EvaLumina for Mac: grading scale and grade distribution.

EvaLumina

On sale

Paper multiple-choice exams, end to end: a different form for every student, optical mark recognition of the scanned sheets, configurable grading scales and item analysis. One Rust engine with native apps for Mac, iPhone and Windows.

Rust SwiftUI WinUI 3 OMR
Live

AI Assistant for Epidemiology Teaching

Active-learning platform for the Preventive Dentistry and Epidemiology course (ESOD 150). It computes a deterministic vocational profile and streams AI-generated feedback (Gemini, Claude), built as an open, reproducible educational-research study with informed consent.

FastAPI LLM Open Science
MVP

Clinical Sterilization Platform

Web system that replaced paper vouchers in the sterilization center of the UACh dental clinic. I directed the project and built the MVP, deployed on a local headless Linux server for security and institutional availability.

Linux Web app Self-hosted

Tools

Languages & frameworks

R (tidyverse) Python Rust Swift / SwiftUI C# / WinUI 3 FastAPI SQL (PostgreSQL / SQLite)

Applied engineering

Computer Vision (OMR) Psychometrics (item analysis) Cryptography (Fernet, Ed25519) LLM Integration (Gemini, Claude) SSE Streaming

Infrastructure

Linux Headless Servers CI/CD Vercel + Railway App Store & Microsoft Store releases

04Teaching & Service

Teaching & mentorship

From 2027 I will direct the Diploma in Clinical Epidemiology. I built an AI-assisted learning platform for the Preventive Dentistry and Epidemiology course, and directed the Honors Program in Medical Research (2020–2023). In the last five years I have supervised 12 theses in dentistry, medical technology, science and business administration, including a master's thesis at Universidad de los Andes.

Academic leadership

Director, Institute of Odontostomatology (Head of the Department of Dentistry), 2024–present and 2019–2020. CNA accreditation self-evaluation committee, 2021–present. Dental School Council, 2021–2025.

Editorial & peer review

Review Editor, Frontiers in Oral Health (2020–present). Reviewer of grants and scholarships for ANID's Medical Sciences panel (2018–present). Reviewer for BMC Oral Health, Frontiers in Endocrinology and BMJ Case Reports.

Awards

Sleep Science Prize for the best presentation, XV Latin American Symposium on Chronobiology (Brazilian Sleep Society, 2019).

Selected invited talks

  • Circadian rhythm mismatch: impact on nutritional health and obesity

    XXIV SOCHINUT Nutrition Congress, Concepción, 2024

  • Healthy lifestyle beyond diet and exercise: impact of circadian rhythms

    XXXIV Chilean Congress of Endocrinology and Diabetes (SOCHED), Viña del Mar, 2023

  • Perio-systemic link: periodontitis and obesity

    Periodontal and Regenerative Medicine Symposium, Chilean Society of Periodontology (SPCh), Santiago, 2023

  • Chronodisruption and future consequences in the fetus

    Chilean Society of Sleep Medicine (SOCHIMES), Santiago, 2021

05Publications

Synced from ORCID
24 items found
2026 #1

Asociación entre obesidad abdominal con severidad en periodontitis en una población chilena. Estudio de corte transversal

Juárez-Membreño A, Céspedes-Barrientos MJ, Aros-Muñoz Y, Halabi D

Revista Odontológica Mexicana

View Paper
2026 #2

Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Tumor-Infiltrating Lymphocytes (TILs), for Patients with Triple-Negative Breast Cancer

Soto M, Poblete MT, Ehrenfeld P, Halabi D

Cancer Investigation

View Paper
2024 #3

Sex-Specific Metabolic Effects of Gestational Chronodisruption and Maternal Melatonin Supplementation in Rat Offspring

Mendez N, Corvalan F, Halabi D, Vasquez A, Vergara K, Noriega H, Ehrenfeld P, Sanhueza K, Seron-Ferre M, Valenzuela GJ, Torres-Farfan C

Journal of Pineal Research

View Paper
2023 #4

Difference in Receptor Activator of Nuclear Factor k B Expression in Tumoral Tissue by Different Periodontal Pathogens

Maher A, Munoz DN, Pavicic MF, Gonzalez M, Ehrenfeld P, Halabi D, Munoz-Kramm A, Munoz H

International Journal of Morphology

2023 #5

From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin

Mendez N, Corvalan F, Halabi D, Ehrenfeld P, Maldonado R, Vergara K, Seron-Ferre M, Torres-Farfan C

Journal of Pineal Research

View Paper
2022 #6

Effects of exercise on irisin in subjects with overweight or obesity. A systematic review of clinical studies

Bernal-Rivas C, Llamunao-Tropa A, Reyes-Barria A, Halabi D, Pavicic F, Ehrenfeld P, Martinez-Huenchullan S

Nutrición Hospitalaria

View Paper
2022 #7

Maternal melatonin treatment rescues endocrine, inflammatory, and transcriptional deregulation in the adult rat female offspring from gestational chronodisruption

Mendez N, Halabi D, Salazar-Petres ER, Vergara K, Corvalan F, Richter HG, Bastidas C, Bascur P, Ehrenfeld P, Seron-Ferre M, Torres-Farfan C

Frontiers in Neuroscience

View Paper
2022 #8

New integrative approaches to discovery of pathophysiological mechanisms triggered by night shift work

Richter HG, Mendez N, Halabi D, Torres-Farfan C, Spichiger C

Chronobiology International

View Paper
2021 #9

Maternal Chronodisruption Throughout Pregnancy Impairs Glucose Homeostasis and Adipose Tissue Physiology in the Male Rat Offspring

Halabi D, Richter HG, Mendez N, Kahne T, Spichiger C, Salazar E, Torres F, Vergara K, Seron-Ferre M, Torres-Farfan C

Frontiers in Endocrinology

View Paper
2020 #10

Fetal programming of adipose tissue function by gestational chronodisruption

Halabi D, Ehrenfeld P, Mendez N, Richter HG, Torres-Farfan C

Sleep Science

View Paper
2019 #11

Fetal Programming of Renal Dysfunction and High Blood Pressure by Chronodisruption

Mendez N, Torres-Farfan C, Salazar E, Bascur P, Bastidas C, Vergara K, Spichiger C, Halabi D, Vio CP, Richter HG

Frontiers in Endocrinology

View Paper
2019 #12

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells

Silva ME, Lange S, Hinrichsen B, Philp AR, Reyes CR, Halabi D, Mansilla JB, Rotheneichner P, de la Fuente AG, Couillard-Despres S, Batiz LF, Franklin RJM, Aigner L, Rivera FJ

Frontiers in Cellular Neuroscience

View Paper
2019 #13

Soluble factors derived from brain pericytes promote neural stem cells to generate oligodendrocytes

Rivera FJ, Silva ME, Lange S, Hinrichsen B, Philp AR, Reyes CR, Halabi D, Mansilla J, Rotheneichner P, de la Fuente AG, Couillard-Despres S, Batiz LF, Franklin RJ, Aigner L

Glia

2018 #14

Calidad metodológica de estudios clínicos de ortodoncia publicados entre 2012-2016

Ruiz Chaura C, Ulloa Riffo N, Halabi D, Muñoz Martínez HD

Odontoestomatología

View Paper
2018 #15

Chlorhexidine for prevention of alveolar osteitis: a randomised clinical trial

Halabi D, Escobar J, Alvarado C, Martinez N, Munoz C

Journal of Applied Oral Science

View Paper
2018 #16

Design and Validation of a Basic Dental Psychomotor Skills Test for Novice Dental Students

Segura C, Halabi D, Navarro N

Journal of Dental Education

View Paper
2018 #17

Gestational chronodisruption leads to persistent changes in the rat fetal and adult adrenal clock and function

Salazar ER, Richter HG, Spichiger C, Mendez N, Halabi D, Vergara K, Alonso IP, Corvalan FA, Azpeleta C, Seron-Ferre M, Torres-Farfan C

The Journal of Physiology

View Paper
2017 #18

GESTATIONAL CHRONODISRUPTION IMPAIRS CIRCADIAN PHYSIOLOGY IN RAT MALE OFFSPRING, INCREASING THE RISK OF CHRONIC DISEASE

Torres-Farfan C, Mendez N, Halabi D, Spichiger C, Salazar ER, Vergara K, Richter HG

Placenta

View Paper
2016 #19

Chlorhexidine mouthwash for the prevention of alveolar osteitis after oral surgery

Halabi D

ISRCTN Registry (trial registration)

View Paper
2016 #20

Gestational Chronodisruption Impairs Circadian Physiology in Rat Male Offspring, Increasing the Risk of Chronic Disease

Mendez N, Halabi D, Spichiger C, Salazar ER, Vergara K, Alonso-Vasquez P, Carmona P, Sarmiento JM, Richter HG, Seron-Ferre M, Torres-Farfan C

Endocrinology

View Paper
2015 #21

Comparison of marginal adaptation between a monoincremental resin with sonic activation and a conventional resin

Villa J, Meier R, Ruiz P, Halabi D

Journal of Oral Research

View Paper
2015 #22

Prevalence of neuropathic symptoms in patients referred for temporomandibular disorder in a Chilean hospital, 2014-2015

Miranda S, Gayoso C, Ruiz P, Halabi D

Journal of Oral Research

View Paper
2014 #23

Association between abdominal obesity and periodontal disease. Cross-sectional study

Juarez I, Hernández M, Letelier C, Halabi D, Araneda C

Journal of Oral Research

View Paper
2012 #24

Logistic Regression Analysis of Risk Factors for the Development of Alveolar Osteitis

Halabi D, Escobar J, Muñoz C, Uribe S

Journal of Oral and Maxillofacial Surgery

View Paper

06Research Funding

Synced from ORCID
Roles from my CV
2022 - 2023 VIDCA-INID210009-03

Melatonin in Chilean berries: a chronobiotic gift of nature

Associate Investigator

Universidad Austral de Chile (VIDCA)

2019 - 2022 FONDECYT 11190711

A white and brown balance of obesity; developmental programming of adipose tissue by chronodisruption

Principal Investigator

ANID (formerly CONICYT)

2018 - 2020 FONDEF ID17AM0043

The fountain of youth: development of an antioxidant, anti-inflammatory and neuroregenerative supplement derived from hops for brain rejuvenation

Postdoctoral Researcher

ANID (formerly CONICYT)